Ibutamoren (MK-677)

 What is Ibutamoren (MK-677)?

Ibutamoren (MK-677) is a non-peptide, orally active growth hormone secretagogue (GHS). It has gained significant popularity in the bodybuilding community due to its ability to enhance muscle mass, speed up recovery, and increase endogenous growth hormone levels. Frequently, the medication is mistakenly categorized as Selective Androgen Receptor Modulator (SARM), but in fact, MK-677 does not interact with androgen receptors. By its essence, the drug imitates the action of ghrelin as well as stimulates the secretion of growth hormone (GH) and insulin-like growth factor 1 (IGF-1).

Originally, MK-677 was developed to treat growth hormone deficiency and muscle wasting conditions. However, due to its physical advantages, the medication found wide application among bodybuilders and fitness enthusiasts seeking supplements that cause muscle gain effects. While other GP treatments require injecting ingredients into the body, MK-677 boasts enhanced convenience since consumers can take it orally. The drug has a long half-life and ensures sustained GH release within 24 hours. The ability to avoid injections with associated inconvenience makes the solution popular among consumers.

Main Effects and Benefits

1. Increased growth hormone levels. An increase in GH and IGF-1 levels has a beneficial effect on muscle building and other changes in the human body, which are welcome in the sports community.
2. Enhanced muscle mass and strength. An increase in GH and IGF-1 levels results in increasing the pace of muscle growth and improving strength and endurance. Moreover, users notice better muscle density.
3. Quick recovery. MK-677 affects sleep favorably, so users ensure quick and effective recovery after intensive training. An increase in the GH level contributes to enhancing overall recovery rates and reducing muscle soreness.
4. Increased appetite. Being an analog of ghrelin, MK-677 stimulates appetite. So, if you want to increase caloric intake for muscle gain, this treatment can help.
5. Bone density improvement. Scientists approved that the MK-677 compound influences bone mineral density positively. Thus, consumers enjoy long-term skeletal health.

Mechanism of Action

The mechanism of action of Ibutamoren is intricate and comprises multiple physiological pathways. Its action is mainly bound to the growth hormone. Below, let’s delve into the issue and consider how the medication causes its effects on the body.

Ghrelin Receptor Agonism

• Binging and activation. Ibutamoren comes as a selective agonist of the ghrelin receptor. When taking the medication, the active ingredient binds to these receptors. Receptors are usually located in the hypothalamus and pituitary gland.
• Ghrelin mimicry. When MK-677 connects to the ghrelin receptor, it imitates its action. Thus, it comes as a replacement for the natural hormone. Since ghrelin is also known as the “hunger hormone”, injected pills can control appetite. Besides, ghrelin is involved in regulating energy homeostasis and promoting GH release.

Stimulation of Growth Hormone Secretion

• Hypothalamic signaling. The hypothalamus is a region of the brain responsible for regulating various endocrine functions. Once ingested MK-677 reaches the hypothalamus, it initiates a cascade of signaling events.
• GH-Releasing Hormone (GHRH). The above-mentioned signaling initiates the process of releasing GHRH from the hypothalamus. GHRH travels to the pituitary gland, where it stimulates somatotroph cells.
• GH release from pituitary. The somatotroph cells in the anterior pituitary gland respond to GHRH by secreting growth hormone into the bloodstream.

GH response to MK-677

Peak GH on day 8: 55.9 ng/mL (±9.7) compared to placebo of 9.0 ng/mL.

Peak GH on day 14: 22.6 ng/mL (±3.0) compared to placebo of 7.4 ng/mL.

Sustained Elevation of GH Levels

• Extended half-life. Some GH secretagogues cause a rapid surge of the GH level, after which it also declines quickly. Unlike such examples, MK-677 has a prolonged half-life of about 24 hours. It means that sustained GH secretion is achieved over a longer period.
• Continuous GH secretion. Since Ibutamoren features a prolonged action, it leads to continuous stimulation of the pituitary gland. This tendency allows for maintaining an elevated GH level steadily and sustainably.

Stimulation of IGF-1 Production

• Liver activation. Once GH is released into the bloodstream, it travels to the liver, where it connects to growth hormone receptors on hepatocytes (liver cells).
• IGF-1 synthesis. The connection of GH to its receptors in the liver stimulates the production and release of insulin-like growth factor 1 (IGF-1). IGF-1 is a powerful anabolic hormone that comes as a vital mediator in multiple growth-promoting effects.
• Systemic effects. IGF-1 circulates throughout the body and affects various tissues, including muscle, bone, and cartilage. It promotes the division and survival of cells, contributing to increased muscle mass and improved recovery.

Changes in concentrations of IGF-I serum during treatment. MK-677 (▪) and placebo (○)

Initial IGF-1 levels: approximately 232 ng/mL.

IGF-1 levels after 7 days of treatment: increased to 256 ng/mL.

IGF-1 levels by day 14: stabilized around 264 ng/mL compared to the placebo group which showed no significant change.

Impact on Appetite and Metabolism

• Appetite stimulation. By activating the ghrelin receptors, Ibutamoren affects appetite indirectly. It’s a known fact that ghrelin impacts the hypothalamic centers that control feeding behavior, stimulating the feeling of hunger. Thus, MK-677 consumers feel hungry more frequently.
• Metabolic effects. Both ghrelin and its alternatives, such as MK-677, participate in the regulation of energy balance and metabolism. Although increased levels of GH and IGF-1 promote lipolysis (fat breakdown), appetite stimulation impedes weight loss.

Insulin and Glucose Regulation

• Insulin sensitivity. Although there is no clear proof of this theory, scientists expect that prolonged use of MK-677, which leads to chronic elevation of GH and IGF-1 levels can lead to changes in insulin signaling pathways.
• Glucose monitoring. The medication impacts insulin and glucose metabolism, so consumers should control the level of glucose in their blood by passing regular tests. This rule is obligatory for individuals who have pre-existing metabolic conditions like diabetes or insulin resistance.

Cortisol Levels

• Cortisol independence. Cortisol is a catabolic hormone that can fight the anabolic effects of GH and IGF-1. Compared to other GH secretagogues and anabolic agents, Ibutamoren does not affect the cortisol level significantly. Due to this feature, MK-677 is suitable for prolonged intake.

Uses

MK-667 (Ibutamoren) drew the attention of both physicians and fitness enthusiasts due to its diverse applications. The supplement comes as an effective treatment for both therapeutic and sports purposes.

Muscle Building and Strength Enhancement

• Anabolic effects. MK-677 is widely consumed by bodybuilders and athletes who want to enhance muscle mass and strength. The increase in GH and IGF-1 levels stimulates muscle protein synthesis, which results in a quicker pace of muscle growth.
• Performance improvement. Keeping GH and IGF-1 levels elevated helps improve body endurance, muscle strength, and overall athletic performance. This feature determines the popularity of the supplement among athletes who are involved in competitive sports or intensive physical training.

Appetite Stimulation and Weight Management

• Appetite enhancement. Being an agonist of the ghrelin receptor, MK-677 stimulates appetite. Due to this feature, individuals who need to gain weight or increase the number of consumed calories per day choose it.
• Weight management considerations. However, like a coin that has two sides, the supplement features both positive and negative effects. While it helps gain weight and recover from illnesses, it impedes losing weight as well. So, if you target losing weight, consider your diet and think about supplement intake.

Anti-Aging Therapy

• Resistance to age-related decline. The human body ages as people grow old. It’s an inevitable process. With age, physical and chemical changes occur in the body. In particular, the level of naturally produced GH and IGF-1 decline, which results in reduced muscle mass, increased fat accumulation, and slower recovery. MK-677 helps mitigate these effects by boosting GH and IGF-1 levels and prolonging a young-looking appearance and healthy physiology.
• Improved recovery and vitality. Increased GH levels improve sleep quality and recovery, contributing to better overall health and vitality in older individuals.

Osteoporosis and Bone Health

• Bone density enhancement. Ibutamoren underwent multiple studies and research to explore its potential to improve bone mineral density. Researchers found out that IGF-1 and GH are essential for bone remodeling and growth. Since MK-677 affects these hormones, the supplement is effective in treating osteoporosis or other bone-related conditions.
• Fracture prevention. By increasing bone density, MK-677 may reduce the risk of fractures. Moreover, when it comes to older individuals or patients with bone-weakening conditions.

Cognitive Function and Neuroprotection

• Cognitive benefits. The newest research suggests that GH and IGF-1 are involved in cognitive function and neuroprotection. Thus, by increasing GH and IGF-1 levels, MK-677 affects cognitive health indirectly.
• Neuroprotective effects. GH and IGF-1 are involved in brain development and repair. It’s clinically approved that they have protective effects against neurodegenerative diseases. This finding provides a foundation for further investigation in the context of brain health.

Sleep Improvement

• Enhanced sleep quality. Growth hormone plays a crucial role in regulating sleep patterns, particularly deep sleep stages. Being an analogue of GH, MK-677 improves sleep quality, which can enhance overall recovery and well-being.
• Recovery aid. Sleep is the period of recovery for our body. Better sleep means more effective muscle recovery and overall physical rejuvenation.

Injury Recovery and Healing

• Accelerated healing. GH and IGF-1 feature anabolic effects that help accelerate the healing of injuries, including muscle strains, ligament tears, and fractures. Since MK-677 increases the GH level, it influences the healing process passively.
• Reduced downtime. Faster recovery from injuries can reduce downtime for athletes and bodybuilders. Since traumas are healed faster, they can return to training within a short time.

Clinical Research and Therapeutic Applications

• Muscle wasting diseases. Nowadays, scientists conduct investigations for the MK-677’s potential to treat muscle wasting conditions such as sarcopenia (age-related muscle loss), cachexia (muscle wasting associated with chronic illness), and muscular dystrophy. Elevated GH and IGF-1 levels can prevent muscle loss and improve quality of life in patients with these conditions.
• Growth hormone deficiency. Being a stimulant of GH release, MK-677 comes as an effective and comfortable treatment for patients with GH deficiency. Its oral administration is more convenient compared to injectable analogs.

Dosage and Administration

Dosage

Starting Dosage: 10 mg per day.

Dosage increase. Note that the dosage is variable. It can be adjusted, depending on individual purposes, response, and tolerance. If consumers feel good during the first week of taking the supplement, it’s allowed to increase the dosage to 15 mg per day. Furthermore, the maximum dosage can reach 25 mg per day. This dosage is considered the upper limit for most users. Consumers can reach it if treatment does not bring the desired effect provided that they feel good, and not side effects are observed:

• 10 mg per day: increases GH levels by about 79% and IGF-1 levels by 52%.
• 25–50 mg per day: increases GH levels by about 82% and IGF-1 levels by 79%.

Placebo vs 10 mg MK-677 vs 50 mg MK-677 in GH deficient men — GH Levels

Placebo vs 10 mg MK-677 vs 50 mg MK-677 in GH deficient men — IGF-1 Levels

Based on the available data, researchers conclude that increasing the dosage to 50 mg does not lead to a significant surge in GH concentration, if compared to a 10 mg dosage. However, a 50 mg dose increases the IGF-1 level significantly. Further examination of various studies reveals a notable diminishing returns effect on IGF-1 levels once the dosage reaches 25 mg per day. It means that the same effect on the IGF-1 level is achieved with dosages of 25 mg and 50 mg. Thus, 50 mg is unnecessarily high for research purposes, while 25 mg per day is optimal for boosting GH and IGF-1 levels.

Consumption

MK-677 is taken orally, usually once a day. Users can take in both with and without water. If you take the Ibutamoren supplement with food, it helps eliminate any gastrointestinal discomfort. Due to its long half-life (~24 hours), a single daily dose is sufficient to maintain elevated GH levels.

Duration

A standard cycle lasts for 8–12 weeks. Once a cycle is finished, it is recommended to take a break to prevent tolerance build-up and to allow the body to reset. A break of 8 to 12 weeks is generally advised.

Tolerance

Prolonged use of MK-677 can lead to the development of tolerance. It’s a condition when the body’s response diminishes over time. This is why breaks are highly recommended after each cycle of supplement intake. The alteration of breaks and intake cycles helps reset the body’s sensitivity to the compound, ensuring continued effectiveness for subsequent consumption.

Monitoring

Consumers are highly recommended to pass regular blood tests to monitor GH and IGF-1, as well as glucose and insulin levels since the supplement can potentially affect carbohydrate metabolism.

Side Effects

• Increased appetite. This peculiarity of the medication is both a pro and a cone. While it’s beneficial for muscle gain, the characteristic comes as a drawback for individuals who attempt to lose weight.
• Water retention. Some users experience water retention, which leads to temporary weight gain.
• Fatigue. Elevated GH levels can lead to increased energy demands. Thus, consumers may feel fatigued since energy is reallocated.
• Insulin sensitivity. Prolonged use can affect insulin sensitivity, which is why consumers should constantly monitor glucose levels.

Storage

• Keep out of children's reach.
• Keep the container tightly closed.
• Store in a dry, cool, and shaded place.
• Protect from moisture.
• Store only in the original container.

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FAQ

Does Ibutamoren affect sleep?

Yes, the supplement improves the quality of sleep. This feature comes as one of the benefits of the medication since good sleep means quick restoration and effective muscle recovery.

Why should I take Ibutamoren?

The supplement helps improve muscle gain, which is why athletes and bodybuilders take it. It stimulates GH production, which helps keep GH and IGF-1 levels elevated.