Kamagra 100 (4 tabs/strip) (Sildenafil Citrate 100mg)

What is Kamagra?

Kamagra comes as a popular drug for fighting erectile dysfunction (ED) on the modern market. It’s widely used because it contains Sildenafil Citrate. The substance demonstrates high effectiveness in coping with ED. Sildenafil Citrate is a substance that slows down or prevents the activity of phosphodiesterase type 5 (PDE5), acting selectively. It was initially researched for treating angina pectoris (stenocardia) — a cardiovascular condition that features chest pain because of lowered blood flow to the heart. However, during clinical trials, the component demonstrated a high effect on the penis, causing its strong erection. Thus, nowadays, the component is used as an active ingredient in medications under brand names like Viagra and Kamagra.

Kamagra affects the penis, enhancing the ability to harden before sexual intercourse. This effect is achieved due to more powerful blood flow to the male organ during its stimulation. Modern manufacturers offer the medication in different forms, including pills, and are ready to satisfy the demands of all consumers. Thus, users can pick suitable options according to their preferences. Kamagra is one of the most popular solutions available on the market. Its popularity is explained by administration flexibility.

Besides ED, Sildenafil is clinically approved to be effective in curing pulmonary arterial hypertension (PAH). The component dilates blood vessels by relaxing the smooth muscle layer of the vascular wall. This property helps decrease the resistance of pulmonary vessels, delay disease progression, and improve exercise capacity.

Main Effects and Benefits

Erectile Dysfunction Treatment

Kamagra is known as a powerful medical drug designed to cope with problems with potency. Millions of men worldwide experience problems with erection, which impacts their quality of life and psychological well-being. Kamagra affects body mechanisms and causes enhancing of the natural erectile response to sexual arousal. Thus, men experience sexual performance and satisfaction. The drug’s effectiveness is clinically approved; moreover, a lot of men report improved erection and successful performance during sexual intercourse.

Mean (±SE) Scores for Domains of the International Index of Erectile Function for Men Receiving Sildenafil or Placebo in the Dose-Escalation Study at Base Line and at the End of the 12-Week Study by Intention-to-Treat Analysis.

Treatment of Pulmonary Arterial Hypertension (PAH)

Elevated blood pressure in the pulmonary arteries is the main sign of this condition. The substance lowers this pressure by relaxing the blood vessels in the lungs. As a result, patients’ resistance to physical exercises improves and clinical worsening is slowed down. Numerous studies have approved a positive effect of Sildenafil on blood flow through vessels, which increases exercise tolerance in PAH patients, enhancing their quality of life and survival rates.

Mean Changes from Baseline, with 95 Percent Confidence Intervals, in the Six-Minute Walking Distance at Week 12 in the Placebo and Sildenafil Groups.

Benefits for Cardiovascular System

The latest research suggests that Sildenafil may offer cardioprotective effects. It has been shown to improve the management of blood circulation through capillaries, reduce oxidative stress, and enhance the ability of myocardia to pass blood. If patients have the above-mentioned conditions and suffer from cardiovascular diseases, the component comes as an effective treatment that helps reduce the pace of condition progression.

The chart shows how blood pressure decreases over time. Mean maximum in supine systolic (A) and diastolic (B) pressures are demonstrated. Changes are explained by an increase in Sildenafil doses in healthy middle-aged volunteers (n 16 per group). Values represent mean standard deviation. 

Exercise Capacity Improvement

Kamagra demonstrated excellent results in improving exercise capacity. Patients become more resistant to fatigue and show higher endurance indicators. This effect is primarily determined by the ingredient’s ability to enhance blood flow and oxygen delivery to muscles, which is important during physical activity. Enhanced blood circulation through vessels causes better cardiac output and stroke volume. Thus, Sildenafil intake helps raise the indicators of physical performance efficiency and reduce fatigue. Numerous studies have approved significant improvements in exercise tolerance. Moreover, enhanced oxygen delivery to blood benefits athletes and sports enthusiasts engaged in intense physical training, which leads to better endurance and quicker muscle recovery.

Correlation between change in peak V̇O2 and baseline PVR at rest in patients treated with either placebo (A) or Sildenafil (B).

Mechanism of Action

Sildenafil Citrate is included in the content of Kamagra as the active ingredient. It operates through a sophisticated biochemical pathway focused on the suppression of the enzyme phosphodiesterase type 5 (PDE5). This pathway affects not only penis hardening but also causes broader implications for vascular health and muscle performance.

Normal Erection Physiology

An erection is a set of complex neurovascular processes, involving psychological, neural, vascular, and hormonal factors:

1. Sexual stimulation. Visual contact, tactile interaction, and psychological impacts trigger the release of neurotransmitters from nerve endings in the penile tissue.
2. Nitric oxide release. Under the influence of these neurotransmitters, the production and release of nitric oxide (NO) occurs. NO is released from cells of the inner lining of blood vessels and nerve endings in the penis.
3. Activation of guanylate cyclase. NO penetrates the erectile tissue, activating the enzyme guanylate cyclase.
4. cGMP production. Guanylate cyclase speeds up the conversion of guanosine triphosphate (GTP) to cyclic guanosine monophosphate (cGMP).
5. Relaxation of smooth muscles. cGMP acts on the erectile tissue, causing its relaxation. Calcium levels between cells are decreased which results in this effect. 
6. Erection. More powerful blood flow causes penis hardening. Veins are compressed with tunica albuginea (a fibrous envelope surrounding the corpora cavernosa), which prevents blood outflow and helps maintain the erection.

Role of PDE5

Phosphodiesterase type 5 (PDE5) is an enzyme primarily found in the smooth muscle cells of pulmonary vessels and corpus cavernosum. Its main function is to degrade cGMP into 5’-GMP. Thus, the enzyme transfers a signal to relax the smooth muscle, which slows down the blood flow to the penis and causes erection weakening.

Substances that activate biological processes and promote the synthesis of cGMP are shown on the figure. Besides, signaling targets that are located between cells, modulated by cGMP, and go downstream are depicted. Finally, the role of phosphodiesterases (PDEs) in cGMP breakdown is reflected. They cause relaxation and improved blood circulation through the body.

Kamagra causes its high therapeutic effect by impeding the production of the PDE5 enzyme. Here’s an exact description of the biological process occurring in the body: