- Active ingredient: Triiodothyronine
- Type: Tyroid
- Form: Oral (pills)
Thyroid hormones are the only known biologically active substances that contain iodine. They have two important functions: in a growing body they are necessary for normal development, especially the central nervous system, and in adults they are responsible for the regulation of metabolism, acting on almost all organs and tissues, they regulate energy expenditure, its speed and volume.
To ensure these functions, the thyroid gland contains large reserves of thyroid hormones. Metabolism of thyroid hormones occurs mainly in the liver, but it is partially carried out in target tissues, for example, in the brain. The level of thyroid hormones in plasma is very finely regulated by the adenohypophysis using TSH with the participation of negative feedback mechanisms. TSH serves as a signal for the production of thyroid hormones, the main of which is T4, which can be converted to T3 mainly in tissues.
Thyroid hormones act mainly through intracellular receptors that affect the expression of certain genes.
Mechanism of action
According to modern concepts, T3 binds to intracellular receptors, which leads to a change in their affinity for T3-sensitive regulatory elements that regulate the expression of certain genes. Thus, T3 affects gene expression, and hence protein synthesis. Usually, a free receptor binds to a regulatory element and suppresses the expression of the corresponding gene, although in some cases it can activate it. By binding to the hormone, the receptor enhances expression (or, conversely, suppresses it). T4 binds to the same receptors, but its affinity for them is much lower than that of T3. However, despite the ability of T4 to bind to receptors, the effect of T4 on gene expression has not been demonstrated. So, in a sense, T4 can be considered a prohormone, since its effect on gene expression is due to the conversion to T3.
There are effective treatments for most thyroid conditions. The method of treating hypothyroidism is obvious - substitution therapy is prescribed.
For medical purposes, in most cases, T4 is prescribed. Both drugs are used in sports, but with slightly different purposes.
Liotimed activates the production of beta-2 adrenergic receptors in adipose tissues. In lipolysis in adipose tissues, the main role is played by the enzyme HSL (hormone-sensitive lipase). Hormone sensitive lipase controls the rate of lipolysis. To activate HSL, the body needs adrenaline and nepenephrine (catecholominas). Epinephrine and nonepinephrine bind to the beta-2 receptors, and so when liothymed stimulates the beta-receptors, there is a proper increase in the ability of catecholomines to activate HSL, reacting to stimulated lipolysis.
Purposes of use
Triiodothyronine (T3) or liothyronine is essentially a thyroid hormone, which may help individuals with fat losing and have an impact during the anabolic and additionally helps in creating GH hormone in a more noteworthy way and increment the anabolism in the body other than fat losing impacts.
Т3 - often used for weight loss instead of thyroxine, they are almost identical in their mechanism of action. T3, in contrast to T4, more actively affects the biochemical pathways of protein catabolism. When both drugs are dosed to achieve the same fat loss, T3 burns much more muscle than T4. Note that T3 is formed from the T4 hormone or the thyroxine hormone as more active form of t4.
T3 stimulates skeletal muscle growth by increasing number and diameter of the muscle fiber and plays a role in the transition of neonatal to adult myosin isoforms.
Liothymed for athletic purposes:
Sportsmen stimulate their metabolic process by using liothymed, which causes a faster conversion of carbohydrates, proteins, and fats. Athletes are interested in stimulating fat burning. Liothymed may administrated in combination with different kinds of anabolic steroids. By combining the drug with anabolic steroids, you can achieve a stronger anabolic effect. Therefore, taking everything right you will have more pronounced muscles. If you have a goal to acquire the perfect balance between a normal physique and large and strong muscles. Liothymed is ideal and will cope with it very effectively.
How to use
Basically, the dosage starts with 25 mcg per day and every 5-6 days increases by 25 mcg per day. And the maximum is 100 mcg per day. Distribute a few tablets throughout the day. The maximum cycle lasts seven weeks. At least six weeks should pass between cycles. In addition, it will return your thyroid gland to normal functioning. It is commonly stacked with clenbutos to make both even more effective at burning fat.
- Average dose: 25 to 100 mcg per day.
- Effective dosage: pyramidal method (25-50-75-100-75-50-25)
- Proven cycle: 5-6 weeks
- Regulates your metabolism
- Burns fat
- Increase anabolic processes and muscle growth
- Please, note that you will lose A LOT more muscle on T3 without any anabolic assistance than you would with it.
- Liothyronine may cause bloodstream sugar to increase. Therefore, high blood sugar can appear, glucose tolerance can modify, and diabetes can worsen. Persons who have diabetes have to monitor their blood sugar closely and tell their doctor about any abnormalities.
- Heart illness: Starting liothyronine may cause the heart to work harder than it has been used to. For this reason people who suffer of angina or other heart illness have to ask their pharmacist how this preparation may affect their medical aspects, about the way their medical condition may influence on the dosing and effectiveness of this preparation and whether any special checking is needed.
- Pregnancy: This preparation is safe to use during pregnancy.
- Breast-feeding: Liothymed passes into breast milk in little amounts. It is essential to continue using thyroid hormone even in case you are breast-feeding. Inform your pharmacist in case you are breast-feeding or intending to breast-feed while administrating liothymed.
- Seniors: Older persons can be more sensitive to the effects of liothymed and should be open-eyed for undesirable effects, especially those referring to the heart.
- Chest pain, discomfort, or tightness
- difficulty with swallowing
- Extreme fatigue
- Fast, slow, irregular, pounding, or racing heartbeat or pulse
- Heat intolerance
- Half-life: 6-24 hours
- Frequency of intake: 1-2 times per day
- Contraindicated in patients with untreated subclinical (suppressed serum TSH level with normal T3 and T4 levels) overt thyrotoxicosis of any etiology and in patients with acute myocardial infarction.
How to store
- Keep away from children
- Keep in a cool, dry place, away from direct sunlight
- Store at room temperature
- Do not use after the expiry date