- Active ingredient: Testosterone Enanthate
- Type: Anabolic steroid (Testosterone derivative)
- Form: Injections
Carrier oil: Grape seed oil
Testosterone is a crucial sex hormone in humans, playing a key role in the development of male reproductive tissues such as testes and prostate, as well as promoting secondary sexual characteristics like increased muscle and bone mass and body hair in males. It also contributes to overall health, well-being, and the prevention of osteoporosis in both sexes. Insufficient levels of testosterone in men can lead to various abnormalities including frailty and bone loss. Testosterone possesses significant anabolic properties, promoting muscle mass increase, protein synthesis acceleration, enhanced recovery rate, and glycogen supply in muscles. It regulates numerous processes in the body and is essential for the well-being of individuals, with applications in the treatment of age-related hypogonadism in the elderly and as a foundation in steroid cycles for athletes.
Mechanism of action:
Testosterone binds to androgen receptors and serves as a precursor to dihydrotestosterone, another biologically active androgen. Dihydrotestosterone is formed through the conversion of testosterone by the enzyme 5α-reduction and exhibits five times greater affinity for androgen receptors. When these hormones interact with the receptor, it undergoes structural changes and transmits a signal to the cell nucleus, where androgenic effects are realized by altering the activity of specific DNA genes. Testosterone can also be converted to estrogen through aromatase, a process known as aromatization. Estrogens, rather than testosterone, predominantly activate feedback through the hypothalamus-pituitary-testes axis, suppressing the secretion of endogenous testosterone when exogenous drugs are administered.
Testosterone is included in the World Health Organization's list of essential medicines, indicating its significance as a vital hormonal drug beyond its anabolic steroid properties. It is used in the treatment of gender dysphoria, male hypogonadism, and certain types of breast cancer. As men age, testosterone levels naturally decrease, and hormone replacement therapy (HRT) or testosterone replacement therapy (TRT) becomes necessary to maintain health and quality of life. HRT ensures that serum testosterone levels remain within the normal range. The decline in testosterone production with age has led to the exploration of androgen replacement therapy.
Mood, spatial ability, attention, memory, and other cognitive functions are influenced by testosterone in humans. Low testosterone levels have been identified as a risk factor for cognitive decline and potentially dementia of the Alzheimer's type.
In both sexes, testosterone plays a role in health, well-being, and the prevention of osteoporosis. Insufficient testosterone levels in men can lead to abnormalities, including frailty and bone loss. Testosterone treatment also benefits adult men with age-related low testosterone levels who experience sexual dysfunction.
Testosterone for Seniors:
Men over 35 who report a decline in well-being are often advised to undergo blood testosterone testing. If their levels are below 12 nmol/L, they are offered hormone replacement therapy. This decision has several positive aspects. It leads to favorable changes in body composition, with increased muscle mass and reduced fat. Sexual function experiences a resurgence, and a certain rejuvenating effect is observed, allowing the body to counteract the negative effects of androgen deficiency. Close medical supervision is necessary, including monitoring of lipid profiles, general clinical blood parameters, estradiol levels, and prolactin levels. Additionally, since natural gonadotropin production approaches zero during HRT, special therapy with the use of gonadotropins may be necessary for individuals seeking to conceive offspring.
Dosage selection for testosterone therapy depends on various factors, including normal testosterone levels, current levels, body weight, body fat percentage, sex hormone-binding globulin (SHBG) levels, and the aromatization process. Dosages for replacement therapy are typically lower than those used by athletes, ranging from 50-200 mg per week.
Testosterone in Sports:
The primary advantage of testosterone is its ability to increase muscle mass and strength. In addition to its anabolic effects, testosterone has a significant androgenic impact. Androgens enter cells and interact with androgen receptors (AR), causing the AR protein to undergo a shape change and become activated. This activation allows AR to enter the nucleus and bind to DNA, leading to various physiological effects.
Rapid weight gain associated with testosterone use is often attributed to water retention resulting from sodium retention and estrogenic effects. While testosterone can help with joint problems, pain, and crunching in the shoulders and knees, nandrolone and growth hormone are considered more preferable in addressing these issues. Testosterone also promotes tissue regeneration, increases overall energy and exercise motivation, prevents overtraining, enhances oxygen-carrying capacity in the blood, and boosts nitric oxide production, resulting in improved muscle pump during training.
The recommended dosage for sports purposes is typically 250-500 mg per week, with an upward dosage adjustment as the athlete's body weight increases. Testosterone cycles typically last 8-10 weeks, followed by 2-3 weeks of post-cycle therapy. In some cases, testosterone is used for longer periods. The maximum dosage of testosterone in high-level professional athletes is usually around 2000 mg per week, as further increases only result in escalated side effects.
To mitigate the development of estrogenic side effects due to aromatization, tests are recommended, and the use of aromatase inhibitors may be necessary. It is optimal to monitor estradiol levels before and during the use of aromatase inhibitors to assess their effectiveness and determine the required dosage. It is highly advisable to seek professional guidance for dosage selection.
- Beginner: 250 mg per week
- The average dosage: 300-750 mg per week
- High dosage: 750+ mg per week
- Increased muscle mass
- Development of male genital organs and secondary sexual characteristics (e.g., deep voice, male facial features, male-pattern hair growth)
- Promotes spermatogenesis and male behavior (sexual, aggressiveness, resoluteness)
- Increased muscle mass
- Fat burning
- Increase in strength indicators
- Boosts libido
- Reduces blood cholesterol levels
- Reduces the risk of heart ischemia and coronary heart disease
- Stimulates erythropoiesis and male-like distribution of subcutaneous fatty tissue
- Influences nitrogen and phosphorus metabolism
- Increased blood pressure
- Increased sexual behavior
- Hemoconcentration (blood clotting)
- Possibility of blood clots in arterial and venous vessels
- Water retention (edema)
- Aggression, agitation, irritability
- Alopecia (baldness of the scalp)
- Insomnia (rare)
- Half-life: 4-5 days
- Frequency of injections: 4-7 days
- Oily solution for intramuscular injection
- Known or suspected carcinoma of the prostate or breast
- Hypersensitivity to the active substance or any of the excipients
- Do not use after the expiry date
- Store at temperatures between 8ºC and 30ºC
- Do not freeze
- Protect from light