The purpose of this cycle is a comprehensive recovery after severe injuries, such as: fractures, ligament ruptures, joint complications requiring surgical intervention, ruptures or even complete muscle tears, micro damages that cause an inflammatory process ,and it needs to be treated.
To heal injuries, there are much more effective drugs than anabolic steroids, especially in relation to injuries of tendons and other collagenic structures. These drugs can be used regardless of your steroid cycle, that is, testosterone and other anabolic steroids are absolutely not required if you want to recover after an injury, for example, any surgery, but if you use steroids during the recovery period, they will be able to make this recovery faster.
Who is it suitable for
This stack is the best combination for either treating existing injuries or for rehabilitation after various surgeries.
You can also use them privately for injury prevention if you know that there is a cycle of heavy training sessions ahead of you, for example, 6 weeks before the сompetitions. The type of sport in this case does not matter, these drugs are suitable for any type of activity, from cycling to swimming, MMA and bodybuilding.
Moreover, these peptides can be used in completely different cases - they are able to heal completely different human tissues, especially in combination with each other. You can treat injuries to bones, muscles, tendons, skin, bowel injuries. TB500 also has a positive effect on the heart tissue and nervous system.
Stack
If you do not want to include anabolic steroids in your injury support cycle, then you can do without them because in addition to it, there are a number of drugs that significantly accelerate recovery after trauma. These drugs in some cases, for example, with injuries to tendons and any other collagen structures, will be first-line drugs. Anabolic steroids have a significant anabolic effect on bone tissue as well as on muscle, but they have a ra-ther weak effect on the restoration of collagen structures. Whereas such agents as growth hormone and IGF-1 (or PEG MGF), as well as TB500 and BPC157, do an excellent job with healing tendons and ligaments and can also have an effect on cartilage structures.
If you want to use preventive measures in relation to possible chronic injuries during the cycle, you simply add those drugs that will be in the main list below (BPC157/TB500/HGH/IGF-1) individually or by combining them. It is possible to increase the effect for tissue regeneration when TB500 is combined with BPC157. In case of tendon injuries and bone fractures, it is better to use BPC157- 157 in addition. This is a fairly common practice and their combination provides a pronounced synergistic regenerative effect.
Preventive measures on steroids cycle or during PCT
As we have repeated - during the cycle, your recovery abilities are much higher than after it and often working with super-maximum efforts at the limit of your body's capabilities - during the cycle you get a lot of microtrauma, both in muscles and tendons. Your strength due to taking anabolic steroids grows very quickly and your muscles may not have time to recover completely, accumulating microtrauma.
The increased protein synthesis in the muscles and the collagen structures that are not somewhat lagging in speed (tendons consist of collagen) make the situation even worse due to the delayed recovery of these collagen fibres. It turns out that the tendons do not have time to recover and accumulate inflammation that you may not even feel during the cycle, but on PCT they manifest themselves in most cases. Partially or completely, this problem can be solved by such drugs as growth hormone / IGF-1, TB500 and BPC157 separately or using together, as we described earlier. If you like strength training with heavy weights, then these drugs will serve you as a prevention of injuries during the cycle. If you have not used them, then you can use them already on the PCT. This will reduce inflammation and significantly help in the recovery process.
It is sometimes not so easy to find out about the presence of an inflammatory process in the body – in this case it is better to rely not on sensations, but on blood tests. The best thing you can do to restore muscles and tendons is to reduce the load (as we said earlier). One of the reasons why during PCT you should not train with large weights. You have to rest. In addition to TB500/BPC157 and growth hormone, you can take curcumin, omega-3 fatty acids and/or CLA daily throughout the PCT.
TB-500
TB-500 supports the treatment of muscle, tendon and ligament injuries. Accelerates healing and reduces the intensity of inflammation. The TB-500 may be recommended in cases of acute injury where, in experience, recovery may otherwise be slow, or in cases of chronic injury where recovery simply does not occur. Types of injury for which this drug may be used include tendinitis and muscle tears or spains, as well as various types of muscle and connective tissue injuries, as well as skin lesions.
In addition, it reduces the risk of pathological adhesions and interstitial adhesions, which can interfere with tissue mobility. No less often this peptide is used for protective purposes. It has a positive effect on muscle tension, helps maintain sufficient flexibility in tendons and ligaments, and therefore may help reduce the risk of injury.TB-500 can significantly speed up the healing of superficial wounds, cuts and burns while reducing the risk of unsightly scars.
How it works
Thymosin Beta 4 plays a vital role in the repair and regeneration of damaged cells and tissues. Following injury, Thymosin Beta 4 is released by platelets, macrophages and many other cell types to protect cells and tissues from further damage and reduce apopotosis, inflammation and microbial growth. Thymosin Beta 4 binds to actin and promotes cell migration, including the mobilization, migration and differentiation of stem/progenitor cells that form new blood vessels and regenerate tissue. Thymosin Beta 4 also reduces the number of myofibroblasts in wounds, resulting in reduced scarring and fibrosis.
TB-500 supports the treatment of muscle, tendon and ligament injuries. Accelerates healing and reduces the intensity of inflammation. The TB-500 may be recommended in cases of acute injury where, in experience, recovery may otherwise be slow, or in cases of chronic injury where recovery simply does not occur. Types of injury for which this drug may be used include tendinitis and muscle tears or spains, as well as various types of muscle and connective tissue injuries, as well as skin lesions.
In addition, it reduces the risk of pathological adhesions and interstitial adhesions, which can interfere with tissue mobility. No less often this peptide is used for protective purposes. It has a positive effect on muscle tension, helps maintain sufficient flexibility in tendons and ligaments, and therefore may help reduce the risk of injury. TB-500 can significantly speed up the healing of superficial wounds, cuts and burns while reducing the risk of unsightly scars . This has been confirmed in several clinical trials.
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BPC-157
As we can see, TB-500 has a huge potential for healing injuries of various origins. It is perfect for our purposes and, as we said above, we can enhance its effect by adding the BPC-157 peptide to the cycle.
Scientists conducted numerous BPC-157 studies on animals, which showed that it has a protective effect that goes beyond the gastric and intestinal tract: BPC-157 helps with stomach ulcers, intestinal damage, such as fistulas and inflammatory diseases, healing of bones and joints, joints, joints sovereigns, as well as with injuries of organs, such as pancreas.
Current studies show that the BPC-157 affects several growth factors usually involved in angiogenesis (blood vessel growth) and other processes involved in regeneration after damage. The crucial importance of gastroprotection under the action of BPC-157 in conditions of tissue inflammation, especially in the formation of stress-induced gastric and duodenal ulcers is emphasized.
BPC-157 has shown many potential health benefits. BPC-157 promotes the healing of various injuries and wounds, demonstrating high cytoprotective activity. BPC-157 may prevent, attenuate or reverse the effects of injury, thus counteracting both arterial and venous thrombosis. BPC-157 can balance collagen synthesis and affect hepatic fibrosis in chronic liver injury.
The effects of BPC-157 also attenuate dermal, muscle, tendon and ligament fibrosis, scarring and promote function recovery. There is an evidence that BPC-157 generates NO under ex vivo conditions. BPC-157 has beneficial effects in animals with stroke, schizophrenia, depression and spinal cord injury within the gut-brain axis. In studies on rats, persistent damage to brain neurons, as well as memory and coordination impairments, were eliminated after the carotid artery occlusion experiment.
Researchers have consistently shown that BPC-157 has a huge number of beneficial effects throughout the body. Theoretically, in the early stages of infection, BPC-157could interfere with viral replication, improve blood vessel integrity and suppress the onset of virus- induced cytokine cascades. In 2017 study has been shown to increase vascular density and accelerate blood flow recovery in ischemic muscle, indicating a stimulatory effect on angiogenesis.
Mechanism of action
BPC-157 interacts directly with the nitric oxide (NO) pathway to regulate blood vessel function as well as stimulating key growth factors. The main mechanism of NO-mediated wound healing is the formation of new blood vessels in a process called angiogenic repair. This means that more oxygen and energy can be delivered to the damaged site and recovery is faster.
BPC-157 is responsible for stimulating the production of angiogenic cytokines such as VEGF, TGF-b and FGF. However, it does much more than these growth factors alone, and its full regenerative potential is extraordinary. It also upregulates the anti-inflammatory gene transcription factor and growth hormone receptors, resulting in an improved systemic recovery response. BPC-157 also stimulates the growth and proliferation of fibroblasts, which are vital for the formation of a structural protein in your skin, bones, and connective tissue called collagen.
During the experiments held on animals, BPC-157 has shown wound healing and cytoprotective activity. BPC-157 facilitates wound healing through accelerated angiogenesis (the process of new blood vessel formation). The wound healing effect affects damage of muscles and tendons, affected vessels of the caecum, spinal cord injuries, portal fibrosis and hemorrhagic cystitis.
Healing of tendons and ligaments
Due to the limited blood supply, spontaneous healing of tendon and ligaments is inherently poor. These soft tissues are very common targets in BPC-157 studies. In 2003, it was found that compared to the severely impaired healing seen in control rats, systemic administration of BPC-157 significantly improved recovery of rats. This has been confirmed biochemically, micro-and macroscopically. Biomechanically, healed tendons (within 14 days) showed increased load to tendon failure and higher functionality. Microscopic analysis showed more mononuclear cells, fewer granulocytes, an increase in fibroblasts and good formation of reticulin and collagen fibers. Macroscopically, the defects were smaller in size and depth, and the overall integrity of the tendon subsequently recovered. Similar results were also shown in 2010 on rat models studying the healing of the medical collateral ligament after surgical incision. The results showed that BPC-157 significantly accelerated the growth of tendon explants; in addition, the migration and propagation rate of tendon fibroblasts in vitro is increased.
Skeletal muscle healing
The positive therapeutic effect of BPC-157 has also been applied to models of traumatic and systemic muscle injury. In 2006 it was reported that the use of BPC-157promoted the healing of injured muscles. More importantly, healing continued for an extended period (72 days) while maintaining functional recovery. We continued to compare the effectiveness of systemic (intraperitoneal) and tropical treatment (in the form of a thin layer of cream) for 14 days in continued gastrocnemius muscle in rats. BPC-157 significantly improved healing macroscopically, microscopically and functionally, with reduced muscle proteolysis. The authors concluded that BPC-157 accelerates skeletal muscle healing after injury. The paper proposed BPC-157 as an effective agent that can improve calf muscle healing when given after injury.
In addition to muscle damage caused by direct injury, a number of studies have shown that BPC-157 may have the ability to restore systemic muscle disorders in response to induced nerve, electrolyte disturbances and/or skeletal muscle wasting, as noted in a 2019 review. Because systemic muscle pain is attributed to infection, autoimmune conditions, disease or drug side effects, it is considered more serios than stresss or exercise-related muscle injury.
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Somatropin (Human Growth Hormone)
The third component of this bundle is growth hormone. HGH supplementation increases connective tissue collagen synthesis in human muscle and tendon, without affecting muscle myofibrillar protein syn-thesis. Thus, HGH supplementation potentially reinforces the supporting connective tissue and could make muscles and tendons less prone to injuries.
In addition to the fact that all three components have a synergistic effect, a bundle of C 157 and growth hormone can strengthen each other even more. There are studies that say that BPC-157-induced increase of growth hormone receptor in tendon fibroblasts may potentiate the proliferation-promoting effect of growth hormone and contribute to the healing of tendon.
The anabolic effect of Somatropin is directed mainly at the connective tissues of the body, consisting of proteins different in structure than muscle proteins. Our muscles consist mostly of contractile proteins, which together form the myofibrillar apparatus. Myofibrils are able to contract and relax, which ensures our ability to move and perform any movements.
Intensive loads on the muscles (in combination with adequate nutrition) contribute to an increase in the number of myofibrils in them, thereby developing muscle growth and muscle strength. But the muscles do not transfer forces to the bones directly, but through the tendons, which must be very strong to withstand these efforts. In addition, the muscles themselves should be elastic and elastic, since under the influence of stress they stretch and contract.
The contractile proteins myosin, actin and actomyosin are responsible for the ability of muscles to contract. And the proteins collagen and elastin are responsible for the structural functions. They give the muscles elasticity and firmness.
In one study, a cycle of growth hormone use increased collagen production in the knee joint, both with and after exercise, but to a greater extent after exercise (1.3 times compared to placebo). But in the muscle tissue, collagen protein synthesis has grown several times stronger than in the tendon. The use of growth hormone in combination with exercise increased collagen synthesis by 5.8 times. The synthesis of myofibrillary protein has practically not changed, which does not directly affect the increase in muscle mass and strength, but due to the increased synthesis of collagen creates conditions under which muscles are able to grow stronger.
https://pubmed.ncbi.nlm.nih.gov/26353786/
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