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Being synthesized in the liver mainly from amino acids such as L-cysteine, L-glutamic acid and glycine, glutathione is considered an interchangeable amino acid, although it is believed that only about 100 mg of this amino acid can be found in foods that the average person eats (usually in protein-rich foods such as meat of various animals), more less of this amino acid is absorbed by the human body and an even smaller amount of it is directly consumed by the body. It has been proven that stress caused by training reduces glutathione levels in the body and negatively affects endurance performance, immunity and recovery rates, and therefore the use of special supplements that regulate glutathione levels has a beneficial effect on an athlete's physical fitness.

TAD-600 is a pharmaceutical glutathione, a powerful antioxidant found naturally in the body. It is used in medical treatments to combat oxidative stress and detoxify the body. Glutathione plays a critical role in protecting cells from damage by free radicals and toxins.

Glutathione is a naturally occurring, very powerful antioxidant. When taking liver supplements like NAC, it works by increasing your body's glutathione levels, which protects your organs from free radicals and toxins that can damage them. Taking glutathione directly provides a much more effective dose. Glutathione is produced by the liver and is also found in fruits, vegetables, and meats.

MECHANISM OF ACTION

Glutathione works by neutralizing free radicals, thus preventing cellular damage. It also supports the detoxification processes in the liver, aids in the metabolism of fats and proteins, and enhances the immune system by regenerating other antioxidants like vitamins C and E. Glutathione is a linear tripeptide with a sulfhydryl group, which includes L-glutamine, L-cysteine and glycine. It plays an important function in protecting the body's cells, being a strong antioxidant. In the human body, a lack of glutathione leads to many diseases, such as Parkinson's disease, tyrosinemia type I, alcohol poisoning and others. In vivo and in vitro experiments have shown that a lack of glutathione can lead to damage to mitochondria and cell death caused by an increase in the number of toxic oxygen species, leading to an increase in the number of free radicals. The neutralization system with the participation of glutathione plays a unique role in the formation of the body's resistance to a variety of influences and is the most important protective mechanism of the cell.

Glutathione binds a huge number of lipophilic compounds (physical neutralization), preventing their introduction into the lipid layer of membranes and disruption of cell functions. Thus, glutathione  improves the stability of the cell membrane, protects the membrane of liver cells, increases the activity of enzymes and the liver and promotes detoxification and regenerative activity of the liver by destroying free radicals.

Glutathione and COVID-19. Adding glutathione to the treatment of severe COVID-19 can reduce life-threatening complications by restoring the effective functioning of the body's defense systems, leading to faster recovery and a milder course of the disease.

WHY INJECTIONS ARE EFFECTIVE BUT PILLS ARE NOT

Since glutathione is not absorbed in the gastrointestinal tract in the most effective way, it is almost impossible to increase its level in the blood with a simple oral administration. Even with the oral administration of an extremely high dose (3 g) of glutathione, it was not possible to achieve any changes in the amount of the substance circulating in the blood. 

In tablet form, glutathione is practically not absorbed by the body. The liposomal form is more bioavailable to the body, but so far, its production is not too active, so it diverges quickly and it is problematic to get it. Intramuscular injections of glutathione are more effective than tablet injections. But the most effective way to use the drug are droppers with glutathione, or at least injection into a vein. In practice, it is the droppers with Glutathione  that provide the best absorption, digestibility, which is why intravenous use is the most effective.

PURPOSE TO USE

Glutathione is useful for almost any person but can be used for various purposes depending on the need.

MEDICAL USE 

People take glutathione  for treating cataracts and glaucoma, preventing aging, treating or preventing alcoholism, asthma, cancer, heart diseases (atherosclerosis and high cholesterol), hepatitis, liver diseases, diseases that weaken the immune system (including AIDS and chronic fatigue syndrome), memory loss, Alzheimer's disease, osteoarthritis, and Parkinson's disease. Glutathione is also used for maintaining the immune system and fighting metal and drug poisoning.

Glutathione is inhaled for treating lung diseases, including idiopathic pulmonary fibrosis, cystic fibrosis, and lung disease in people with HIV. Healthcare providers administer glutathione via intramuscular injections to prevent the toxic side effects of cancer treatment (chemotherapy) and for treating male infertility. Healthcare providers also give glutathione intravenously to prevent anemia in kidney patients undergoing hemodialysis, prevent kidney problems after heart bypass surgery, treat Parkinson's disease, improve blood flow and decrease clotting in individuals with atherosclerosis, treat diabetes, and prevent the toxic side effects of chemotherapy.

ANTIAGE USE

This substance is produced in our body all the time. Its amount depends on the diet, level of physical activity, lifestyle and age. After 20 years, the rate of glutathione synthesis begins to drop. By the age of 35, its level decreases significantly, the first signs of aging appear, and systemic diseases can make themselves felt. Prevention of glutathione deficiency can slow down these processes. Also, droppers with this antioxidant increase the effectiveness of cosmetic procedures and improve the quality of life in general. Glutathione deficiency is an acquired condition associated with aging, male gender, comorbidities, and smoking. Reduced intake of fresh vegetables and fruits can also lead to deficiency.

USE TO IMPROVE SPORTS ACHIEVEMENTS 

Glutathione is a very popular supplement used by athletes because it has many beneficial properties and is consumed in response to physical exertion. It is considered the “main antioxidant” and is the main detoxification and anti-inflammatory agent in every cell of your body. It is especially useful in the world of athletics and other sports due to its ability to prevent and eliminate tissue damage, unnecessary inflammation, infections, muscle weakness and overwork.

As an antioxidant, glutathione helps improve athletic performance by protecting cells from damage caused by the formation of free radicals during exercise, especially when their levels exceed the body's ability to defend against them. For example, an athlete returns to training and preparing for competitions after a long break, begins a new and difficult training cycle, or an athlete is exposed to such stresses as being on high ground (for example, in mountains), in a place where smog accumulates, or in very hot or cold climatic conditions. 

Studies have shown that if a person experiences these types of stress, they may experience a significant decrease in glutathione levels in the body. The increased antioxidant protection provided by glutathione can boost endurance, accelerate body recovery, and support athlete health during the competitive season. Moreover, it is believed that maintaining glutathione levels in the body protects athletes from infections and recurrent diseases that can somehow prevent athletes from achieving their best results in training and competitions. 

This protection is achieved by improving the absorption of nutrients and amino acids by cells, which are important for the functioning of the immune system, in particular for lymphocytes and phagocytes. Athletes can benefit from glutathione, which can be expressed in increasing endurance, strengthening the protection of the immune system and accelerating the recovery of the body after training. 

A 2003 study involved a 61-year-old experienced athlete, a runner, who was injected with four doses of glutathione (1000 mg) intravenously for 36 days. As a result, after running 18.4 miles (29.6 km), he was able to significantly improve his time. In particular, it took him 5 minutes less time to cover this distance last time than the first time; in other words, the result was improved by 7.2%.

WHAT CAN AN ATHLETE GET FROM GLUTATHIONE 

  • Relieve muscle and joint pain
  • Repair the damage
  • Regulate inflammation
  • Stimulate the synthesis and growth of muscle protein
  • Reduce the risk of diseases or infections
  • Prevent muscle fatigue
  • Increase energy levels
  • Improve the functioning of the cardiovascular system
  • Increase physical activity and endurance

EFFECTS 

Glutathione has a wide range of effects on the body. Below we list some of the most important ones.

OXIDATIVE STRESS

Glutathione is best known for its ability to prevent oxidative stress. Oxidative stress occurs when antioxidants are insufficient to fight free radicals, which leads to damage to cells and tissues. Oxidative stress can manifest itself in many biological systems and cause many negative consequences. Glutathione is superior to other antioxidants in preventing oxidative stress because it can neutralize a wide range of free radicals, either by directly binding to them or by blocking their absorption. 

GLUTATHIONE DEFICIENCY

Physically active people often have glutathione deficiency. During exercise, the level of glutathione decreases rapidly due to an increase in its absorption by tissues. The more a person trains, the more exhausted they become. This makes oxidative stress more severe and widespread. This can cause a variety of problems, such as muscle and joint pain, weakness, and vulnerability to infections and injuries. 

IMPROVING MUSCLE PERFORMANCE 

After a workout, oxidative stress primarily affects your muscles. It can cause muscle fatigue, which reduces the amount of effort your muscles can perform. Because of this, the ability to progress during training decreases, and it may have to be completely suspended. The time required for tissue repair is also affected by a decrease in glutathione levels, which leads to more intense and prolonged pain in muscles and joints, as well as injuries. Glutathione supplements combat oxidative stress by reducing muscle fatigue and promoting recovery after intense physical exertion. 

ENHANCE IMMUNITY 

Glutathione plays an important role in the immune system. It increases or reduces inflammation to a certain level by controlling white blood cells. It also limits the amount of negative cytokines, proteins that send signals that disrupt the proper inflammatory response. Glutathione also helps the immune system prevent and cure infections and diseases. Athletes are more susceptible to them because intense physical activity reduces immunity. Glutathione helps by commanding certain white blood cells, such as NK and T cells, to fight bacteria and viruses. 

INFLAMMATION

The inflammation process occurs not only in injuries such as sprains of muscles or ligaments; it is also activated to eliminate microscopic muscle tears that occur instantly during exercise. Because of this, glutathione is considered an incredibly effective regenerating nutrient, which is especially useful for those who exercise regularly. 

GLUTATHIONE AND VIRAL INFECTIONS

Studies suggest that higher levels of glutathione improve the body's response to viral infections. Glutathione protects immune cells through its antioxidant properties and helps immune system cells function properly. It can suppress the replication of various viruses at different stages, preventing increased viral load and massive inflammatory cell release in the lungs ("cytokine storm"). A study by De Flora et al. showed that preventive use of N-acetylcysteine (NAC, a precursor of glutathione) over six months significantly reduces the incidence of flu and flu-like episodes, especially in high-risk elderly individuals. In conditions like lung cell damage and inflammation in severe ARDS patients, a deficiency of reduced glutathione  worsens lung cell damage due to oxidative stress and inflammation. This can be effectively treated with NAC, which also helps prevent coagulopathy in COVID-19 patients.

GLUTATHIONE AND COVID-19

Endogenous glutathione deficiency worsens oxidative lung damage caused by SARS-CoV-2, leading to severe symptoms such as acute respiratory distress syndrome, multiple organ failure, and death. People with glutathione deficiency are more susceptible to uncontrolled SARS-CoV-2 replication, resulting in increased viral loads. COVID-19 patients with moderate to severe disease have lower glutathione levels, higher ROS levels, and a higher oxidative-reductive status (ROS/GSH ratio) than those with mild disease. Prolonged and severe COVID-19 infection in a patient with significant glutathione deficiency suggests that glutathione depletion correlates with increased viral replication and lung damage. Higher cellular glutathione levels result in milder clinical symptoms and lower viral loads.

The antiviral effect of glutathione is non-specific, suggesting it is also active against SARS-CoV-2. Restoring glutathione levels in COVID-19 patients would be a promising treatment approach. Long-term oral administration of N-acetylcysteine has been tested as an effective preventive measure against respiratory viral infections. N-acetylcysteine is widely available, safe, inexpensive, and can be used off-label. Parenteral injection of reduced glutathione, which is more bioavailable than NAC, may be an effective therapy for severe COVID-19 cases.

BENEFITS OF GLUTATHIONE 

TAD-600 is indicated for various medical conditions, including:

  • Liver diseases: Helps in the treatment of hepatitis and other liver disorders by detoxifying harmful substances.
  • Cancer treatment: Used to mitigate the toxic side effects of chemotherapy and radiation therapy.
  • Immune support: Enhances the immune system, especially in conditions like AIDS.
  • Neurodegenerative diseases: Benefits patients with Parkinson's disease and Alzheimer's disease by reducing oxidative stress in the brain.
  • Cardiovascular diseases: Helps in the treatment of atherosclerosis by improving blood flow and reducing blood clotting.
  • Lung diseases: Effective in treating pulmonary diseases like idiopathic pulmonary fibrosis and cystic fibrosis.
  • Metabolic disorders: Aids in managing diabetes and preventing complications associated with it.
  • Male infertility: Used to improve sperm quality and treat infertility in men.
  • General health: Supports overall health by preventing aging, enhancing memory, and maintaining cellular health.

DOSAGE AND ADMINISTRATION

In medicine, for various liver lesions, such as alcoholic cirrhosis, glutathione is used in courses. Most often, these are droppers in a dosage of 1200-2400 mg per day for 30 days. The full cycle for healthy people who want to increase antioxidant protection includes about 10 procedures. The duration of one procedure is about 30 minutes, and the intervals between droppers are 1-7 days. The intervals between procedures, as well as the dosage and the number of necessary droppers are calculated individually for each individual. 

One cycle usually includes about 10 intravenous infusions, then maintenance administration of antioxidants can be carried out regularly. The duration of action is also individual and depends on many factors. The course can be repeated after a while. 

Similar cycles are carried out in medical clinics as wellness/antiage procedures. Most likely, this method will be the closest to our goals. Glutathione can also be administered intramuscularly, which greatly facilitates administration. 

Based on the information that can be found on the Internet about the use of glutathione in sports practice, some athletes give one injection every 3 days, someone once a week throughout the entire cycle. Dave from the YouTube channel RxMuscle - The Truth in Bodybuilding says he uses 200 mg every day. Unfortunately, there are no exact protocols and it is important to focus on your own feelings here.

SIDE EFFECTS

While TAD-600 is generally well-tolerated, some potential side effects may include:

  • Allergic reactions: Rash, itching, or swelling.
  • Injection site reactions: Pain, redness, or swelling.
  • Gastrointestinal issues: Nausea or vomiting.
  • Headache or dizziness.

PRECAUTIONS

  • Allergies: Inform your healthcare provider of any known allergies.
  • Pregnancy and breastfeeding: Use under medical supervision.
  • Chronic conditions: Patients with chronic diseases should consult their doctor before starting treatment.
  • Avoid concomitant use with sodium menadione bisulfite, cyanocobalamin, calcium pantothenate, sulfonamide preparations and tetracyclines.

STORAGE

TAD-600 should be stored in a cool, dry place away from direct sunlight. The reconstituted solution should be used immediately to ensure effectiveness and prevent contamination.

COMPOSITION

Each vial of TAD-600 contains 600 mg of reduced glutathione. The product is typically administered via intravenous or intramuscular injection.

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