Hair loss, a notable side effect of Anabolic Androgenic Steroids (AAS), is a substantial concern for users. The metabolite of Testosterone, Dihydrotestosterone (DHT), plays a pivotal role in hair loss by shrinking hair follicles in genetically predisposed individuals, leading to androgenic alopecia. To mitigate this side effect, users often explore anti-hair loss medications like Finasteride and RU-58841 as preventive measures. Below is a detailed comparison of these two options:

Finasteride

  • Action: A steroidal anti-androgen that functions as a 5-alpha-reductase inhibitor, reducing DHT levels and its effects like hair loss and acne.
  • Administration: Oral.
  • Mechanism: It inhibits the conversion of Testosterone into DHT by targeting the 5-alpha-reductase enzyme.
  • Side Effects: May cause erectile dysfunction, loss of libido, and depression due to systemic reduction in DHT levels.
  • Application: Effective and convenient when Testosterone is the only steroid used.
  • Limitations: Ineffective against DHT derivatives like Proviron, Masteron, and Winstrol as these are already active forms of DHT.

RU-58841

  • Action: A non-steroidal anti-androgen that is topically applied.
  • Administration: Topical.
  • Mechanism: Binds to androgen receptors in the application area, blocking DHT and its derivatives from attaching, preventing effects like hair follicle miniaturization and enhanced sebum production.
  • Side Effects: Minimal to none as it doesn't impact systemic DHT levels.
  • Application: Effective against hair loss and acne, irrespective of the type of AAS being used, including DHT and its derivatives.
  • Dosing: Typically involves applying 50mg of liquid solution to the scalp and affected areas daily.

Which is Better During a Cycle?

  • Convenience: Finasteride is more convenient with Testosterone-only cycles.
  • Broad Spectrum Efficacy: RU-58841 is superior in preventing hair loss and acne during cycles involving various AAS, including DHT derivatives, due to its action independent of 5-alpha-reductase.
  • Side Effect Profile: RU-58841 has a preferable side effect profile due to its localized action and lack of systemic DHT reduction.

Conclusion:

Choosing the right preventive measure is crucial in the battle against hair loss and acne induced by AAS use. While Finasteride is convenient and effective in cycles involving only Testosterone, its systemic action and associated side effects, coupled with its ineffectiveness against DHT derivatives, limit its utility. In contrast, RU-58841, with its localized action, minimal side effects, and broad-spectrum efficacy, is a more versatile option for those using varied AAS cycles. However, individual response and application convenience should also guide the choice between these anti-hair loss strategies.