Muscle Growth Factor (MGF) is a naturally occurring hormone produced in damaged muscle tissue, often a result of activities like intense training. Its primary function is to facilitate the repair and development of new muscle tissue through cell proliferation. Research has consistently shown that the most effective stimulation of MGF occurs during training that combines both eccentric and concentric loads.
After a workout, our Insulin-like Growth Factor 1 (IGF-1) and MGF levels are at their peak. This elevation is partly attributed to the reduction of IGF-1 binding proteins (such as IGFBP-4) after exercise, which bind to IGF-1 and inhibit its anabolic effects. The post-workout window is thus an ideal time to harness the benefits of MGF and IGF-1.
To optimize the administration of these growth factors, it's important to mimic the natural release pattern while enhancing their potency since exogenous administration provides a significantly larger quantity than the natural release, artificially inducing the myogenesis process.
Protocol Overview:
The protocol for utilizing MGF and IGF-1 consists of two distinct phases, each with a specific purpose:
Phase 1 - Cell Proliferation (Weeks 1-4):
During the first four weeks, the focus is on cell proliferation triggered by the exogenous administration of PEG-MGF. Dosages range from 1000-3000mcg per week, divided into two applications weekly. Intramuscular injection is recommended since MGF is an autocrine hormone belonging to skeletal muscle. Administer it immediately post-workout when IGF-binding proteins are at a minimum.
Phase 2 - Cell Differentiation (Weeks 5-8):
Following the cell proliferation phase, weeks 5-8 involve cell differentiation induced by IGF-1 LR3. This phase aims to differentiate the cells created during the proliferative activity of MGF. Administer IGF-1 LR3 at a dose of 50-120mcg daily, using subcutaneous injection because IGF-1 is an endocrine hormone. Inject it within 6-12 hours post-workout to avoid inhibiting endogenously produced MGF activity. This protocol should also be followed on rest days. In some cases, it can be co-administered with insulin (following the usual protocol with ultra-rapid insulin) to reduce the breakdown of IGF-binding protein IGFBP-3, thereby extending the half-life of IGF-1.
This protocol is designed to maximize the benefits of both MGF and IGF-1 for muscle growth. However, it's essential to consult with a healthcare professional or expert in this field before embarking on such a regimen. The use of growth factors should be approached with caution and an understanding of potential risks and side effects.
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